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Degradation from freeze-thaw cycles does not always produce visible changes

When we separated the cohort into cats receiving iron supplementation and those not, the iron-supplemented group showed a less pronounced increase in UGCR across CKD stages, whereas the group without iron supplementation retained a clearer stage-dependent trend (Supplementary Figure S4)

it integrates into the broader antioxidant network, working alongside others like superoxide dismutase and catalase

The antioxidant enzymes (SOD, GRx and GPx) showed a decrease in their activities in preeclamptic women as compared with normal women, indicating the loss in their antioxidant capacity, whereas a significant increase in catalase activity showed its compensating regulatory role in response to the increased oxidative stress

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