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In the SAL/NAL OD group ( n = 9), [GSH] significantly decreased over the 120 min ( Z = 2.55, p = 0.01) and administration of NAC in the NAC/NAL OD group ( n = 8) at the time of acute precipitated withdrawal produced no significant difference in [GSH] over the 120-min ( Z = 1.1, p = 0.26)

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Investigating the preventive roles of antioxidants, assessing long-term safety, and exploring lifestyle impacts on oxidative stress are crucial areas for further study