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10.1016/j.toxlet.2015.06.012 80 KaushalG

de Morais, J

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In this scheme, the propensity of the reactive metabolite of a cytotoxic drug to cause adverse biochemical effects on cellular DNA and proteins depends on the balance between formation of the reactive metabolite from the parent drug, and the rate of elimination of both the reactive metabolite and the parent drug by alternative metabolic routes