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GH plays a role in dermal thickness and collagen biosynthesis, reversing age-related skin changes (Laron, Pediatric Endocrinology Reviews )

Tumour-associated macrophages (TAMs), often polarised to an immunosuppressive M2 phenotype by NF-B signalling, secrete cytokines such as interleukin-10 (IL-10) and transforming growth factor-beta (TGF-) [65]

Annual Review of Immunology

Understanding what we actually know versus what is speculated is essential

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