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An inverse correlation between miR-142 and SIRT1 expression was observed in the brains of long-lived aged rhesus macaques ( In astrocytes, epigenetic regulations in their senescence remains under investigation (Labarta-Bajo and Allen, 2025), while several studies have reported the histone acetylation and increased H3K27ac enrichment in AD astrocytes Li X

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however, the lesions were in an actively oozing/erosive phase, and we were concerned that repeated topical applications could prolong maceration and maintain a moist wound environment, potentially increasing the risk of wound breakdown and framework exposure