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Whereas the tumor necrosis factor alpha (TNF-)-mediated activation of MKK4 (SEK1) via its downstream target JNK leads to the induction of apoptotic cell death, the activation of MKK6 activates p38 subgroups of MAPK, which phosphorylate a wide range of potential targets in response to inflammatory cytokines and cellular stress

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Above a certain size, it is difficult to restore the tooth shape and tooth contacts, so ceramic fillings should be preferred

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doi: 10.1038/s41467-019-10741-9