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For further information on safer colchicine prescribing, see: bpac.org.nz/bpj/2014/september/safer-prescribing.aspx (published in 2014

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69,70 Small nerve fibers may become sensitized following increased distal terminal injury and regeneration in the presence of neurotrophins

The appeal is that it may influence several smaller things that add up: Matrix signaling Collagen support Repair environment after stress Visible skin quality Recovery-oriented tissue turnover That is a more grounded story than the usual hype cycle

Common localized injury dosing is 200300 micrograms (mcg) daily, split into two injections near the injury for 24 weeks