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Vitamin B12 has a very low toxicity profile, and the European Food Safety Authority (EFSA) has not established an upper safe limit, as excess B12 is readily excreted in urine

Evidence involving oral supplements or topical products does not automatically substantiate claims for an intravenous infusion

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DOR, duration of response

27 Treatment Strategies A number of treatment strategies exist to address disc degeneration, ranging from biological therapies to nonoperative and operative management

At 16.67 mg/mL, each injection equals 12 U-100 units (0.12 mL) , for approximately 6 mg per week [18]