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CX-4945 and TBB inhibit CK2 [28], which phosphorylates a variety of proteins that regulate DDR, circadian rhythms, cell survival, senescence, and apoptosis

Ursodeoxycholic acid Ursodeoxycholic acid (UDCA) is well known for dissolving cholesterol stones, which can stabilize cell membranes, safeguard mitochondria, mitigate bile salt toxicity, and be employed in the treatment of primary biliary cholangitis and cholestatic liver disease

When GA is administered, AMPK is phosphorylated, and acetyl-CoA carboxylase 1 (ACC1) and ACC2 are both inactivated by AMPK, therefore inhibiting the conversion of acetyl-CoA to malonyl-CoA, thus blocking fat synthesis (J et al., 2023)

Qian Y, Qi F, Chen Q, Zhang Q, Qiao Z, Zhang S, et al

These preclinical findings support the further development and advancement of these small molecules as potential therapies for type 2 diabetes and obesity

Shamsad A, Gautam T, Singh R, Banerjee M