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Extracellular cystine will be transported into cell and reduced to cysteine for the synthesis of glutathione (GSH) ( In addition to the above typical pathways that regulate cellular susceptibility to ferroptosis, several others also play a role

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However, the relationship between these mechanisms and our observation that GSH is required to evade polyubiquitylation remains unclear

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PMID: 34830477 Bioresour Technol Rep2023 Nov 10, 101696