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the side-effect burdens of pharmacotherapy and possible drug interactions

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Changes in upstream protein cascades influence downstream metabolomic profiles, directly affecting phenotypes 20,21

This results in a pathological state with high cellular tryptophan and low kynurenine.[ref] Theres still more research that needs to be done here, so check back for updates

Kupffer cell-mediated differential down-regulation of cytochrome P 450 metabolism in rat hepatocytes

(2) it causes the accumulation of lipids in muscle fibers and liver, resulting in obesity, fatty liver and other diseases