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10.1016/j.bbabio.2018.05.019 [DOI] [PubMed] [Google Scholar] 39.Liu YJ, Ji DM, Liu ZB, Wang TJ, Xie FF, Zhang ZG, Wei ZL, Zhou P, Cao YX

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The molecule isnt known to produce tolerance or downregulation that would require breaks

Fact 07 Argireline shows 48.9 percent subjective wrinkle improvement versus 0 percent placebo in clinical trial when delivered effectively, with topical penetration as the main efficacy ceiling

Retinoids intensify skin sensitivity and can make copper peptide tolerance unpredictable