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During the last step of the matrix protein import cycle, PEX5 is recycled back into the cytoplasm in a monoubiquitin-dependent manner for further rounds of import or is subjected to proteasome-mediated turnover of dysfunctional receptors 49

Azelaic acid, ascorbic acid, kojic acid, arbutin, chemical peels, and laser therapy also offer benefit but none of these therapies have shown uniformly satisfactory results

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[50], suggested that the reduction of the intracellular environment as cells progress from G1 to G2/M phase, as shown in our study, may protect genomic DNA from oxidative damage upon brake down of the nuclear envelope