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Therefore, it is important to highlight how these models have proven to be invaluable in our quest to understanding mitochondrial disorders such as LS

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To bridge this gap, more studies should focus on pre-clinical evaluations, moving towards clinical trials, and eventually integrating these findings into clinical practice

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As a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, tirzepatide works by enhancing insulin secretion in response to meals, suppressing glucagon release, slowing gastric emptying, and reducing appetite