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In addition, involvement of the elevated level of Pro in regulation of expression of genes of PCS, metallothionine-2 (MT-2), glutathione reductase (GR), and glutathione synthetase (GS) was recently reported in As-exposed plants (Ahmad and Gupta, 1981)

References Rosenberg SA, Restifo NP

Finkelstein JD: Methionine metabolism in mammals

In patients with lower back pain, the efficacy of flupirtine was comparative with that of tramadol and superior to placebo, whilst the incident of treatment-emergent adverse effects and related study discontinuations was significantly lower in the flupirtine group relative to the tramadol group