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How a body-water loss of just 12% measurably impairs attention, working memory, concentration and mood (Ganio 2011 in men, Armstrong 2012 in women)

These effects were linked to the activation of signaling pathways such as FAK-paxillin, suggesting a role in regulating cellular movement and structural organization in experimental systems

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4 A study of two participants cannot establish: The frequency of uncommon adverse events Safety across different ages or health conditions Safety with other medicines or substances Long-term safety Safety through other routes Clinical effectiveness The authors themselves stated that further studies were needed

Community-reported research protocols cite 812 week cycles, though those are not clinical recommendations

The result: effective, sustainable weight loss that goes beyond diet and exercise alone. While individual results vary, many patients lose 1015% of their body weight within the first year of therapy