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In terms of the magnitude of fat mass reduction in controlled research settings: Semaglutide (GLP-1 alone): ~1015% body weight Tirzepatide (GLP-1 + GIP): ~1622% body weight Retatrutide (GLP-1 + GIP + Glucagon): ~2429% body weight (Phase 2 data) This stepwise increase with each additional receptor target is a remarkable demonstration of pharmacological synergy and has driven enormous interest in the triple-agonist research space

Hypofiltration was defined as eGFR 140mmHg) (p 185 mmHg) at randomisation

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A phase II trial involving capmatinib and nabulizumab as secondary treatments for advanced/metastatic EGFR wild-type NSCLC patients, who had not received anti-PD-1/PD-L1 before, revealed that a group with elevated MET expression (evidenced by immunohistochemistry in 50% of tumor cells = 3 + or gene copy number (GCN) 5 or IHC in METex14 + = 2 +) exhibited a six-month PFS rate of 68.9%