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Poly (ADP-Ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic

Ilhan ZE, Brochard V, Lapaque N, Auvin S, Lepage P

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[DOI] [PMC free article] [PubMed] [Google Scholar] 265.Gabriely G, Quintana FJ

This vulnerability arises from multiple converging factors comprising increased oxidative stress, disrupted iron homeostasis, depleted antioxidant reserves, and altered lipid composition (Park et al., 2021

The AIMS (Amplification of Inter-Methylated Sites) method uses a combination of the methylation-sensitive SmaI and its isoschizomer methylation-insensitive PspAI enzyme to construct fragments to which adaptors are ligated to perform a further whole-genome PCR reaction [94]