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Actually, these two nuclear receptors acted indirectly by interfering the binding of other transcriptional factors, like HNF4-, to specific elements of APOC3 , thereby further inhibiting APOC3 gene transcription [26, 27]

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PMCID: PMC4798095

Bakeeva LE, Eldarov CM, Vangely IM, Kolosova NG, Vays VB

Histological analyses also showed reduced lipid accumulation in the livers of mice with hepatic miR-27a overexpression, suggesting reduced hepatic steatosis