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42 It has now been established that some IL-6 effects are reliant on HO-1 activity as HO-1 has a central mechanistic action in the regulation of the complex antioxidant system and is a key node in multiple signaling pathways, including IL-6/Jak/STAT3

Nutrients 13(6):1951

The Alabama Board of Medical Examiners specifically addressed this in its May 26, 2026 notice, prohibiting administration even with patient consent forms