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found that Ras Selective Lethal 3 can induce ferroptosis in primary melanocytes, as reflected by suppressed cell growth, mitochondrial dysfunction, increased ROS production and iron ion accumulation [76]

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The critical role of heavy metals in causing oxidative damage does suggest that this is a significant mechanism that is also involved in metal toxicity, and thus, this has prompted scientists to investigate the ability of various natural or synthetic antioxidants in preventing and attenuating metal-induced biochemical alterations

Wen, C., Chiang, C., Lee, C., Lin, Y., & Tsai, J

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