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Available from: pmid:32678947 29

doi: 10.1038/onc.2015.60 51 DeveciHAAkyuvaYNurGNazroluM

By combining metformin and simvastatin, the transition of SREBP2 precursor to its mature form is inhibited, resulting in a downregulation of SREBP2 mature form, making it challenging to act as a transcription factor to alter GLUT1/6 levels