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share the binding affinity) but have the additional advantage of increased protease resistance that motivates also our work

This stark dichotomy between its efficacy in APL and its limitations elsewhere underscores a fundamental principle in cancer pharmacology

To remove free DSPE-mPEG 2000, the PEG-CeNPs were thoroughly purified by sequentially treating the nanoparticles with high-speed ultracentrifugation at 450,000 g for 2 h and filtration using an Amicon centrifugal filter with a 30 kDa cutoff molecular weight