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The transdermal composition of claim 2 wherein polymer is selected from one or more of polyethylene glycol, methacrylate copolymers (Eudragits), Acrylic copolymer, Polyster Film/copolymer of ethylene and vinyl acetate, Poly (Butyl methacrylate, methyl methacrylate), cellulose polymers (carboxymethylcellulose, ethyl cellulose, hydroxypropylmethylcellulose hydroxypropylcellulose), polyvinylpyrrolidone, polymer of acrylic acid crosslinked with allyl ethers of polyalcohols (carbomer / carbopol)

doi: 10.1089/ham.2013.1053

Itraconazole synergistically increases therapeutic effect of paclitaxel and 99mTc-MIBI accumulation, as a probe of P-gp activity, in HT-29 tumor-bearing nude mice