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identified that maltodextrin nanoparticles can attach to anionic sites on the cell membrane early in endocytosis and penetrate the BBB through a cholesterol-dependent exocytosis pathway[150]

Second, research in animal models suggests that semaglutide activates GLP-1 receptors in the central nervous system, particularly in the brainstem area postrema and nucleus tractus solitarius, which are regions responsible for controlling nausea and vomiting responses