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FIGURE 4 Tripeptide-1 protects skin cells against oxidative stress and enhances collagen and glycosaminoglycan (GAG) production

Bringing any drug through Phase II and Phase III to regulatory approval costs hundreds of millions

Additionally, itaconic acid promotes the pentose phosphate pathway, leading to ROS production, enhancing its anti-inflammatory and antibacterial properties [103]

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e,h , Observed adducts and fragments in negative ( e ) and positive ( h ) ion ESI-MS, their calculated monoisotopic masses, as well as the expected and observed number of 18 O incorporations