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Studies of glutathione transferase P1-1 bound to a platinum(IV)-based anticancer compound reveal the molecular basis of its activation

5 Caution should be used with tramadol in patients with seizure history and in combination with other serotonergic medications, due to its effect of lowering seizure threshold and possible development of serotonin syndrome, respectively

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Formation of other (mixed) species such as GnatS34SG will be carefully evaluated and the ratios will be corrected accordingly

The enzyme has a redox function and is localized in the membrane of the endoplasmic reticulum