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Several the transition state analogues of MTAN have been designed and tested as potential antibiotics in in vitro and in vivo experiments

At the cellular level, Al 3+ toxicity may progress to the nucleus involving interactions with the plasma membrane, nucleic acids, histidine, and other nucleophilic residues within the cytoskeleton, which are key to its phytotoxic effects [3]

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The conversion from cyanocobalamin to active forms requires several enzymatic steps and adequate amounts of other nutrients including folate, riboflavin, and various minerals