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In PD models, Stat1 ablation alleviated -synuclein fibril-induced suppression of microglial ULK1 transcription and autophagy, which is consistent with the mechanism whereby -synuclein disrupts microglial autophagy through STAT1-dependent repression of ULK1 expression

Expression of SOD and catalase is indirectly regulated by SIRT3 through deacetylation of FOXO3 106,107

Quantification of 2HG enantiomers 2HG quantification in SCD erythroblasts was performed as we previously described 24 by liquid chromatographymass spectrometry (LC-MS/MS) after derivatization using N-(p-Toluenesulfonyl)-L-phenylalanyl Chloride (TSPC) on the LC-ESI-MS/MS system

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many patients ultimately progress to fibrosis/cirrhosis and liver failure