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Therefore, many studies examined the effect of SAM administration as a monotherapy or an add-on to antidepressant treatment

doi:10.1186/s13075-023-03043-5

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A funnel plot is suggestive of the presence of most of the studies outside the plot, hence it is likely that significant publication bias is present DISCUSSION Obesity has severe health consequences, with each 5 kg/m 2 increase in BMI beyond the normal range linked to a 30% increase in mortality and a potential reduction in life expectancy by up to 10 years.[16] Conversely, significant weight loss is associated with metabolic and non-metabolic benefits

44 Meanwhile, new research shows Akkermansiaor its secreted protein, P9can trigger GLP-1 release in gut cells and improve glucose control in mice, which could offer the same benefit in humans

11 As a result, genetic testing for HLA-B*1502 is only recommended in patients of Southeast Asian descent