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Tricarboxylic acid cycle (TCA)-associated metabolisms were the main metabolic pathways reprogramed during establishment and passage of patient-derived xenograft model By using relative quantitative metabolites enrichment analysis and metabolic pathway analysis, we found glycolysis/gluconeogenesis, TCA metabolism and TCA-associated metabolic replenishment pathways were highly associated with the metabolomic difference of PC vs

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Indeed, in vitro experiments showed that not iodide, but iodine (in the form of Lugol) is the main precursor for the formation of these -iodolactone compounds (16)

Engineered cytokines for cancer and autoimmune disease immunotherapy