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JMJD6 regulates histone H2A.X phosphorylation and promotes autophagy in triple-negative breast cancer cells via a novel tyrosine kinase activity

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The corresponding positions of the conserved domain and 3D structure were shown in Fig

Abbreviations ASD: Autism spectrum disorder, KD: Ketogenic diet, GFCF: gluten-free-casein-free diet, ATEC: Autism Treatment Evaluation Test, CARS: Childhood Autism Rating Scale, ABC: Abnormal behavior checklist, 6-GSI: Gastrointestinal Severity Index, GI: Gastrointestinal symptoms, NGI: Non-gastrointestinal, ADOS-CSS: Total Autism Diagnostic Observation ScheduleCalibrated Severity Score, TNF-: Tumor necrosis factor-, MMP- 9: Matrix metalloproteinases, IL- 6: Interleukin- 6, SRS: Social Responsiveness Scale, CBCL: Social and Attention Problems syndrome of Child Behavior Checklist, IL- 1: Interleukin- 1, TARC: Thymus and activation-regulated chemokine, RSV: Resveratrol, VPA: Valproic acid, LCPUFA: Long-chain polyunsaturated fatty acid Conclusion and Recommendations There is no nutritional intervention that has a definitive and clear effect in managing ASD