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If the cause of a persons B12 deficiency is their diet, they may not require further shots or only require them once or twice per year

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doi:10.1371/journal.pone.0033944 Lederman RJ, Mendelsohn FO, Anderson RD, Saucedo JF, Tenaglia AN, Hermiller JB, Hillegass WB, Rocha-Singh K, Moon TE, Whitehouse MJ et al (2002) Therapeutic angiogenesis with recombinant fibroblast growth factor-2 for intermittent claudication (the TRAFFIC study): a randomised trial

This disease is called pernicious anemia. Vitamin B Complex and Diabetes : Vitamin B12 has been shown to cause symptomatic improvement among patients with severe diabetic neuropathy