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Noyce said that there isn't an agreed definition of "heavy use," but a ballpark figure is using more than 10 to 15 canisters more than once a week, citing his own research, while the Dutch Poison Centre classes puts it at inhaling 50 or more balloons in a single session

Notably, based on the results of the above-cited 15-year follow-up study, concluded in 2011, epithalamin-treatment patients had significantly lower mortality compared to the control group [12]