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The improvement of oocyte vitrification resulting in pregnancy and live birth rate increases comparable to using fresh oocytes, which has offered a chance to cryopreserve oocytes for upcoming practice, presenting women with the possibility to delay their motherhood ( Tobacco Smoking, Coffee and Alcohol Abuse Tobacco smoking markedly affects the reproductive health of both men and women, albeit acting in different ways

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this invention provides a method for obtaining an immunomodulatory polynucleotide that has an optimized modulatory effect on an immune response, or encodes a polypeptide that has an optimized modulatory effect on an immune response, the method comprising: creating a library of non-stochastically generated progeny polynucleotides from a parental polynucleotide set