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Given the muscle weakness that is part of the prime disturbance, vascular failure [66,71,72,73,74,75,76,77,78,79,80,81,82], stroke [20], traumatic brain injury [21], spinal cord compression [28,29], vessel occlusion and similar noxious procedures [66,71,72,73,74,75,76,77,78,79,80,81,82] were all specifically highlighted in the literature

One of the underlying mechanisms could involve the increased stiffness associated with an increased collagen density

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(2022) reported that in prostate cancer stem-like cells, inhibition of the Notch-1 pathway by PF-03084014 ( -secretase inhibitor) increases the anti-cancer activity of docetaxel by reducing cell growth, sphere formation and inducing apoptosis [97, 98]