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The role of cytochrome P450-mediated detoxification in insect adaptation to xenobiotics

Under the catalysis of peroxidases (ALOXs), reactive substances interact with polyunsaturated fatty acids (PUFAs) on the membrane of organelles to produce reactive lipids (RLS), such as malondialdehyde (MDA), which in turn activate ferroptosis 31

J Biomater Sci polymer Ed 19(8):969988 Pickart L, Margolina A (2018) Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data