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10.1093/jnen/nly102

A ribonucleoprotein (RNP) approach delivered by Nucleofection (V4XC-2032

Reported pathways include TGF- signaling, antioxidant defense (superoxide dismutase, glutathione peroxidase), extracellular-matrix gene expression (collagen types I and III, decorin, perlecan), and inflammatory cytokine modulation

While the RDA is 2.6 mcg, studies show that higher doses of up to 1,000 mcg (1 mg) daily are generally considered safe during pregnancy, especially when treating deficiency [*]