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In 2 compartment models, where the drug equilibrates between blood and (for example) adipose tissue, during elimination there is a sharp initial fall in blood levels followed by a gradual subsequent fall

L.SabinR.FrahlerK.HarrisC.PetrikoB.et al (2011)

Focal adhesion dynamics: Cell migration requires coordinating adhesion formation at leading edge and adhesion dissolution at trailing edge

J Chem Theory Comput

These local reactions typically resolve quickly and diminish with continued use as technique improves

[DOI] [PMC free article] [PubMed] [Google Scholar] 123.Stockli J, Zadoorian A, Cooke KC, Deshpande V, Yau B, Herrmann G, et al