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In some embodiments, the otic formulation or composition comprises about 0.7% by weight of the poloxamer

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In preclinical research environments, the individual components of BPC-157/TB-500 BLEND have been studied for their interaction with intracellular signaling pathways, cellular communication networks, cytoskeletal organization, and extracellular matrix-associated processes

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In addition to the effects of SMAD3 antagonism on MMP9, treatment with both TGF 1 and SIS3 was also able to rescue the downregulation of claudin-5 mRNA and protein (Figures 6a and b) compared with TGF 1 treatment alone