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Recently, modern alternatives to such distribution and access challenges have come to light, such as single-dose slow-release implants, film-based vaccines 94 , and microneedle-based patches that could reduce reliance on the cold chain and ensure vaccination even in situations where qualified HCP are rare or in high demand

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Melioidosis as an emerging global problem

Fernndez-Gins R, Encinar JA, Escoll M, Carnicero-Senabre D, Jimnez-Villegas J, Garca-Yage J, Gonzlez-Rodrguez , Garcia-Martinez I, Valverde M, Rojo AI, et al

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Mitochondrial permeability might be also facilitated by external factors such as mitochondrial calcium loading, pH changes, thiol oxidation, and activation of the adenine nucleotide translocator (ANT)