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The systemic effects of GBM include decreased T cell counts and functionality, small secondary lymphoid organs, and lower class II MHC expression levels systemically [31, 35]

This condition may be associated with immunosuppression, in view of the lower availability of this amino acid for the immune cell metabolism [1]

After entering the nasopharynx, pathogens escape recognition and clearance from host immune cells by mimicking the host molecular structure or altering their own antigens, escaping the mucus and adhering to the upper respiratory epithelium ( The manner in which bacteria, viruses and fungi induce an immune response after invasion is somewhat different (Figure 1)

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