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Lastly, a consensus exists that ferroptosis synergizes with other PCD types in ocular pathologies: autophagy impairment drives ferroptosis of CECs in DED, and necroptosis shares overlapping mechanisms with ferroptosis in RPE cell degeneration (90, 123)

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1 Introduction Osteoarthritis (OA) is among the most prevalent degenerative joint diseases globally, affecting more than 500 million people worldwide and ranking as the leading cause of disability among adults aged 50 years and older ( Ferroptosis, first reported in 2012, is a novel form of cell death distinct from classical apoptosis, pyroptosis, and necrosis ( Due to the possible critical role of ferroptosis in OA, there has been a surge of interest in elucidating its molecular mechanisms and exploring potential therapeutic strategies