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References 1 Current Pharmaceutical Design (PubMed)Sikiri P, et al

Genes 14:1285 Gillette-Guyonnet S, Van Kan GA, Alix E, Andrieu S (2007) IANA (International academy on nutrition and aging) expert group: weight loss and Alzheimers disease

A low-fat diet may decrease the risk of arsenic-related kidney damage [141] Antioxidant-rich foods such as berries, citrus fruits, spinach, and nuts enhance cellular defense mechanisms and neutralize ROS [142] Adequate hydration supports arsenic excretion and kidney detoxification [143] Avoiding arsenic-contaminated foods, including rice and groundwater from endemic regions, is crucial for reducing dietary exposure Nutraceuticals and functional foods may offer protective benefits without adverse effects Regular physical activity improves metabolic efficiency and detoxification [144] Avoidance of tobacco and alcohol, both of which exacerbate renal impairment, is strongly advised Stress reduction techniques, such as yoga and meditation, contribute to overall kidney health by modulating chronic inflammation Routine medical checkups are crucial for the early detection of nephrotoxicity and for enabling timely intervention [145]

Sterol feedback regulation is characteristic of all genes involved in cholesterol biosynthesis and homeostasis, whereas cAMP-dependent regulation is unique, suggesting that CYP51A1 may play a tissue-specific role distinct from cholesterol biosynthesis

Second, some data could not withstand corrections for multiple comparisons because diverse metabolites and neurotransmission components were analyzed in comparative and correlational fashions