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doi: 10.1016/j.maturitas.2014.07.010 79 De SetaFCarusoSDi LorenzoGRomanoFMirandolaMNappiRE

c , HeLa cells were untreated or treated with Camptothecin (CPT, 1 M, 30 min, left) or 5-Aza-2-deoxycytidine (5-aza-dc, 100 M, 30 min, right) as indicated

The second is intranasal dosing at 600-2,700 mcg per day, split into 2 or 3 sprays

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Therefore, IGF-1 deprivation seriously contributes to the progressive malnutrition of cirrhotic patients, increasing the vulnerability of the liver to an inflammatory and oxidative microenvironment with mitochondrial dysfunction