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284 In addition, PD-L1 upregulation was observed in tumor cells after V-9302 treatment, and the combination of V-9302 and anti-PD-1 antibody showed greater anti-tumor efficacy than either drug alone

Thus, a tenuous balance between free haem and CO plays key roles in cancer development and chemoresistance 7 , although the underlying mechanisms are not fully understood

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Moreover, it has been shown that stomach cancer is more likely to develop as a result of the oxidative stress brought on by CagA-positive bacteria (74), in which H pylori CagA produces cells with oxidative DNA damage by inducing spermine oxidase (SMO), and a portion of these cells are apoptosis-resistant and therefore highly susceptible to developing cancer (75)

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doi: 10.1016/j.bbrc.2023.04.043 17 DaenenKAndriesAMekahliDSchepdael VanAJouretFBammensB