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Mitochondrial H 2 O 2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

Elevated expression of miR18a was confirmed by multiple probes in the array (Appendix Table S3)

[DOI] [PMC free article] [PubMed] [Google Scholar] 105.Vilchez D, Simic MS & Dillin A

Based on mRNA expression both sequences reduced expression to ~45% of the non-silencing control (nsSiRNA

This is mainly caused by disturbances in DNA hypomethylation, plasma homocysteinemia, increases in S-adenosylhomocysteine (SAH), reduction in S-adenosylmethionine (methyl donor), and an unfavorable plasma lipid composition (Stefanska et al., 2012)