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Health Risks of Vitamin B12 Deficiency If not treated immediately, a B12 deficiency may pose serious health complications, including permanent nerve damage, mental health concerns, and a heightened risk of heart disease

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Recommendation for clinical practice: Patients with type 2 diabetes treated with Metformin, especially those with concomitant use of proton pump inhibitors, should be monitored for vitamin B12 deficiency and/or hyperhomocys- teinemia

Possible adverse reactions, considered rare and exceptional, include: Acne is reported as a relatively common symptom when very high doses are administered at once

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Gender-specific Hormones There are also hormonal imbalances specific to each gender