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2020, www.sciencedirect.com/science/article/abs/pii/S0976566220304409, Wen Ting Hao, et al

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FIGURE 2 The recent studies correlate the NP toxicity with the consequences of ROS generation (Wang et al., 2017

Notably, experimental evidence demonstrates that DAB2IP linearly inhibits both the JAK2/STAT and PI3K/Akt pathways, an integrated model further proposes the existence of significant crosstalk between these pathways, potentially forming a feed-forward loop that amplifies the dysfunction of VSMCs (33)