Jahan I, Tai B, Ma J, Hussain S, Du H, Guo L, Wang G, Adegoke TV, Ma L, Xing F (2023) Identification of a novel Bacillus velezensis IS-6 nudix hydrolase Nh-9 involved in ochratoxin A detoxification by transcriptomic profiling and functional verification
Learn more about Dextrin Asiaticoside comes from the super popular skin-soothing ingredient, Centella asiatica
Activity was calculated using the extinction coefficient of the product formed (9.6 mM 1 cm 1 ) and was expressed as nmoles of CDNB conjugated/minute/mg of total protein
Abbreviations RIF: Radiation-induced fibrosis ROS: Reactive oxygen species ECM: Extracellular matrix components RIHD: Radiation-induced heart disease TGFs: Transforming growth factors ILs: Interleukins -SMA: -Smooth muscle actin MMPs: Matrix metalloproteinases TIMPs: Tissue inhibitors of metalloproteinases HSC: Hepatic stellate cell EMT: Epithelial-mesenchymal transition EndoMT: Endothelial-mesenchymal transition CSF1R: Colony-stimulating factor receptor-1 CSF1: Colony-stimulating factor 1 CTGF/CCN2: Connective tissue growth factor PDGF: Platelet-derived growth factor MMT: Macrophage-myofibroblast transition Treg: Regulatory T cell SASP: Senescence-associated secretory phenotypes FBW7: F-box and WD40 repeat domain-containing 7 TPP1: Telomeric protection protein 1 LXA4: Lipoxin A4 HIF-1: Hypoxia-inducible factor-1 MAPK: Mitogen-activated protein kinase AMPK: AMP-activated protein kinase NOX4: NADPH oxidase 4 CUGBP1: CUG-binding protein 1 TBK1: TANK-binding kinase 1 LRP5/6: Low-density lipoprotein receptor-associated protein 5/6 WISP1: Wnt-1-induced secreted protein RNS: Reactive nitrogen species NLRP3: NOD-like receptor protein 3 Nrf2: Nuclear factor erythroid-2-related factor 2 Keap1: Kelch-like ECH-related protein 1 RIPK3: Receptor-interacting protein kinase-3 SOD: Superoxide dismutase STING: Stimulator of Interferon Genes cGAS: Cyclic guanosine adenosine phosphate synthase cGAMP: Cyclic dinucleotide 23 cyclic GMP-AMP IRF3: Interferon regulatory factor 3 XBP1: X-box binding protein 1 BINP3: BCL2/adenovirus E1B interaction protein 3 DNMT: DNA methyltransferase PDK1: Pyruvate dehydrogenase 1 GLUT1: Glucose transporter protein 1 mTORC1: Rapamycin complex 1 FAO: Fatty acid oxidation STAT6: Signal transducer and activator of transcription 6 UPS: Ubiquitinproteasome system DUB: Ubiquitin-dissociating enzyme YAP: Yes-associated protein FAT10: F-associated transcript 10 FPS: FAT10-proteasome system ALKBH5: Alkylation repair homolog 5 FOXM1: Forkhead box M1 MZF1: Myeloid zinc finger protein 1 BCL6: B-cell lymphoma 6 protein SIRP3: Sphingosine-1-phosphate receptor 3 ROCK: Rho-associated convoluted helix kinase DGKA: Diacylglycerol kinase PPAR: Peroxisome proliferator-activated receptor RAAS: Reninangiotensinaldosterone system CoQ10: Coenzyme Q10 NMN: Nicotinamide mononucleotide CCL11: CC motif chemokine 11 CAF: Cancer-associated fibroblast FSTL1: Follistatin-like 1 PET: Positron emission tomography Vit E: Vitamin E PTX: Pentoxifylline TPL: Triptolide RTKIs: Receptor tyrosine kinase inhibitors IPF: Idiopathic pulmonary fibrosis RA: Rosmarinic acid GSPs: Grape seed proanthocyanidins PPIs: Proton pump inhibitors ACEIs: Angiotensin-converting enzyme inhibitors DFO: Deferoxamine VEGF: Vascular endothelial growth factor eNOS: Endothelial nitric oxide synthase 2-ME: Methoxyestradiol MSCs: Mesenchymal stem cells Ad-MSCs: Adipose-derived mesenchymal stem cells BM-MSCs: Bone marrow-derived mesenchymal stem cells UC-MSCs: Umbilical cord-derived mesenchymal stem cells HGF: Hepatocyte growth factor References Berry CE, Abbas DB, Lintel HA, Churukian AA, Griffin M, Guo JL, et al
Other metabolic pathways regulated by shear stress In addition to glycolysis, FA metabolism, and mitochondrial respiration, shear stress regulates other metabolic pathways in ECs with relevance to aging and vascular dysfunction
Several studies have found a link between ASD and ferroptosis [239]
